ARA-290

R 927.00

Peptide Name

ARA-290 (Cibinetide)

*please note due to solubility PBS is needed for ARA-290 Reconstitution

Chemical Name/Structure

Chemical Name: L-pyroglutamyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparagyl-L-seryl-L-serine
Molecular Formula: $C_{51}H_{84}N_{16}O_{21}$
Structure/Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (also referred to as Pyroglutamate Helix B Surface Peptide)

CAS Number

CAS Number: 1208243-50-8

Research Areas of Focus

Researchers are actively conducting in vitro and laboratory studies on ARA-290 to investigate its molecular behavior in the following areas:

Innate Repair Receptor (IRR) Activation: Studying how the peptide selectively binds to the erythropoietin-CD131 heteroreceptor (IRR) without triggering erythropoiesis (red blood cell production).
Neuropathic Pain and Neuroprotection: Investigating the peptide's capability to protect and repair damaged small-fiber nerve networks, particularly in metabolic or systemic nerve loss models.
Inhibition of Pro-inflammatory Cytokines: Exploring the downstream signaling mechanisms (such as the NF- $\kappa$ B pathway) that lead to a decrease in the production of destructive tissue inflammatory mediators.
Tissue Salvage and Wound Healing: Analyzing the role of ARA-290 in promoting cellular survival, migration, and proliferation under severe metabolic stress or hypoxic (oxygen-deprived) conditions.
Endothelial Function and Microvasculature Support: Assessing how the compound influences capillary blood vessel survival, local blood flow regulation, and the integrity of cellular linings under high-glucose stress.

RESEARCH-USE NOTICE

This product is supplied by Biolabs for laboratory and research purposes only. It is not intended to diagnose, treat, cure, or prevent any medical condition and should not be used as a substitute for professional medical advice or treatment.

Any information provided is for general research, product identification, storage, and handling purposes only. The purchaser is responsible for using and storing the product appropriately and in accordance with applicable regulations.