PT-141 Nasal Spray
PT-141 Nasal Spray
PT-141 Nasal Spray
Peptide Name
PT-141 (Bremelanotide) Nasal Spray
Chemical Name/Structure
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Chemical Name: N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2→7)-lactam, monoacetate
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Molecular Formula: $C_{50}H_{68}N_{14}O_{10} \cdot C_{2}H_{4}O_{2}$
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Structure: A synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone ($\alpha$-MSH).
CAS Number
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CAS Number: 1607799-13-2 (Acetate salt); 189691-06-3 (Free base)
Research Areas of Focus
Researchers are actively conducting in vitro and laboratory studies on PT-141 in lyophilized vial formats to investigate its biochemical properties in the following areas:
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Melanocortin Receptor Binding Affinity: Studying the selective activation profiles of the peptide across the central nervous system's melanocortin receptors, primarily targeting $MC_{3}R$ and $MC_{4}R$.
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CNS-Mediated Arousal Pathways: Investigating how the compound acts on central nervous system pathways to modulate neurotransmitters, such as dopamine terminals in the medial preoptic area (mPOA), to influence sexual motivation and desire rather than peripheral blood flow.
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Reconstitution Dynamics for Intranasal Delivery: Evaluating the solubility, stability, and chemical integrity of lyophilized PT-141 when reconstituted in sterile, buffered saline solutions specifically formulated to optimize nasal mucosa absorption.
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Synergistic Vasoactive Co-treatments: Exploring potential interactions and outcomes when combining central-acting melanocortin agonists with peripheral phosphodiesterase-5 (PDE-5) inhibitors in non-clinical assay designs.
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Transient Cardiovascular Dynamics: Analyzing the systemic impact of central melanocortin activation on transient blood pressure fluctuations and heart rate variability in biological research models.
IMPORTANT RESEARCH-USE NOTICE
This product is supplied by Biolabs strictly for legitimate laboratory, analytical, and scientific research use only.
It is not supplied or approved for human or veterinary use and must not be consumed, injected, inhaled, administered, applied topically, compounded, or used for any therapeutic, cosmetic, diagnostic, preventative, or personal purpose.
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The purchaser is solely responsible for ensuring that the product is acquired, stored, handled, tested, and used by suitably trained personnel in an appropriate research environment and in compliance with all applicable laws, regulations, institutional requirements, safety standards, and laboratory procedures.
By purchasing this product, the purchaser confirms that it will be used exclusively for lawful research purposes and accepts full responsibility for its possession, handling, and use.